喜树碱,≥98% (HPLC)
- 产品编号：C0180
- 中文名称：喜树碱
- 英文名称：(S)-(+)-Camptothecin
- 英文别名:Camptothecine
- CAS号:7689-03-4
- 分子式:C20H16N2O4
- 分子量:348.35
- 纯度:≥98% (HPLC)
- MDL号:MFCD00081076
订货信息：
产品规格价格(RMB)
- C0180-20MG(99.5%标准品)120
- C0180-100MG220
- C0180-500MG800
性能描述
| 试剂纯度 |
≥90% (HPLC) |
| form |
powder |
| mp |
260 °C (dec.)(lit.) |
| solubility |
chloroform/methanol (4:1): soluble5 mg/mL |
| storage temp. |
2-8°C |
Biochem/physiol Actions
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
理化性质： 浅黄色针状结晶(甲醇-乙腈) ，分解点：264℃～267℃，[α]25D +31.3。(氯仿-甲醇) 。在紫外光下表现强烈的蓝色荧光，和酸不能生成稳定的盐。
