2-脱氧-D-葡萄糖,≥98% (GC), crystalline
- 产品编号：D0103
- 中文名称：2-脱氧-D-葡萄糖
- 英文名称：2-Deoxy-D-glucose
- 英文别名:2-Deoxy-D-arabinohexose, 2-Deoxyglucose
- CAS号:154-17-6
- 分子式:C6H12O5
- 分子量:164.16
- 纯度:≥98% (GC), crystalline
- EC号:205-823-0
- MDL号:MFCD00151328
订货信息：
产品规格价格(RMB)
- D0103-1G190
- D0103-5G850
- D0103-25G3100
- D0103-100G9500
性能描述
| 纯度 |
≥98% (GC) |
| form |
crystalline |
| color |
white to off-white |
| mp |
146-147 °C(lit.) |
Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.†
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
其他名称：2-脱氧-D-葡萄糖/2-去氧-D-葡萄糖/D-2-脱氧葡萄糖/2-Deoxy-D-glucose/D-2-脱氧葡萄糖;D-2-脱氧葡萄糖;2-去氧-D-葡萄糖;2-脱氧葡萄糖;2-去氧-D-葡糖;2-脱氧-D-葡糖;2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose;2-deoxy-d-arabino-hexos;2-DG
性状与溶解：2-脱氧-D-葡萄糖(2-DEOXY-D-GLUCOSE)（以下称2DG）为白色粉状晶体，味臭，略甜，易溶于水，部分可溶于甲醇、乙醇、丙醇、丁醇。不溶于氯仿、石油以及甲苯。
2-脱氧-D-葡萄糖是天然抗代谢物类抗生素,具有能够抑制病毒感染、酵母发酵、病菌及肿瘤细胞生长等多种生理药理效应。具有抗病毒、抗菌、抗癌、抗癫痫、抗衰老等作用,用于预防病毒及病原菌感染等,可防止HSV、HIV、流感病毒等病源菌引起的传染病，可治疗疱疹等，主要用于畜禽各种病毒病、免疫抑制病的预防和治疗，也可作为细菌及支原体感染的辅助治疗，在医药及化妆品等行业具有广泛的应用前景。
